Tag: research

2017 wasn’t all bad: a good news story that will change the world forever

Now that the end is nigh for 2017, I think we’d all agree that the last twelve months have had more than their fair share of memorable moments. We’ve seen Donald Trump begin his reign of power, Kim Jong Un shoot off his shiny new intercontinental missiles, the Grenfell tower block burn down in the UK, and the bell ring for round one of the political bout that is Brexit. It’s hard to remain upbeat with a steady trickle of terrorist atrocities, a never-ending migrant crisis, and Middle East conflicts that show no sign of ending. There has, however, been a lot of good news that has slipped under the radar. This blog post is about my choice of what didn’t get the publicity it deserved. Not everyone will agree, and I’d be interested to know what other people would choose (feel free to comment below).

Get ready to say ‘bye bye’ to some very nasty diseases

The past year has witnessed some incredible advances  developments that look set to revolutionise our lives for ever – and in a very good way. My pick of this year’s most important medical breakthroughs came in the form of a new type of medical treatment called gene therapy. 2017 has seen the coming of age of a new gene editing technology that has been the talk of science town. Called CRISPR (pronounced ‘crisper’), this is an innovation that lets lab workers precisely write to and edit a person’s genetic code. It’s getting so accurate that next-generation ‘CRISPR 2.0’ (which debuted in October) has made it possible to snip and chop just as you would correct a spelling mistake on a word processor.

With this emerging therapy, it is quite possible that conditions like haemophilia and sickle cell disease will go the way of smallpox and be eradicated from planet Earth. The source of the problem – the faulty DNA code – will be fixed with a bit of genetic jiggery-pokery. Back in March, a French teenager was apparently cured of sickle cell disease with a gene therapy. It was causing him agonising ‘sickle cell crises’ in his limbs and abdomen, each bout lasting up to a week. His internal organs were also slowly failing. Now the 14-year-old boy has been “given his life back” – the genetic error he was born with has been erased.

In November, gene therapy was used for the first time in a 44-year-old man afflicted with Hunter’s Syndrome – a hereditary condition causing stunted growth, low IQ, and progressive disability. And just last week the USA drug approval authority (the FDA) gave the all-clear for gene therapy to treat a rare form of blindness. The countdown has now begun until we create ‘cures’ for the evilest of degenerative diseases, like Huntingdon’s disease and Motor Neurone disease.

It doesn’t stop with the hereditary conditions that you are born with. Researchers have realised that Type 1 Diabetes could also be consigned to the history books with these advances – they have been devised a way to genetically program the liver to produce the insulin that the body lacks. For people with diabetes, this should mean no more daily injections and finger-prick sugar tests.

CRISPR also means that we we have a serious chance of healing many types of cancer – or at least keeping them at bay better than ever before. A fantastical new cancer treatment, called CAR-T therapy, sees doctors taking a big slug of a person’s blood, extracting a sample of their immune cells, then genetically programming them to attack their cancer. These super-powered infection-fighters are injected back into the blood so that they set about killing the cancer as if it were a virus. A few days ago, research results showed that it worked against lymphoma (a cancer of the blood) and right now it is being piloted in brain tumours and a host of other cancers.

As exciting as they are, none of these advances have the shock and awe of a Harvey Weinstein sex scandal, so don’t sell papers or get the clicks. Neither do they usually arrive in ‘Eureka!’ apple-dropping breakthrough moments, but from the slow drip-drip-drip of steady progress from countless researchers chipping away at the rockface. It’s going to take patience –many years – until the investment pays out. But these good news stories will probably go on to effect all of our lives, and is certainly a far better bet than any bitcoin.

Thanks for reading. Feel free to add your thoughts and share important news stories that you think slipped under the radar in the comments below.

 

Fireworks image credit: chensiyuan via Wikimedia

The vaccine controversy that isn’t controversial

Polio is a disease that should be long dead by now. Some readers will be old enough to remember rooms full of ‘iron lungs’ – grotesque life-support machines that did the breathing for children left paralysed by this deadly infection. With their small heads poking out through a tight rubber seal, steam engine-like contraptions sucked and pressed on the child’s chest in the hope that their strength would recover. Polio infection was also called ‘infantile paralysis’ and it struck terror into the hearts of parents everywhere. The viral disease starts out like a mild flu then attacks the brain and spinal cord. A blight on humankind, children who survived could be left with monstrous deformities. Read more

The Science of the Midlife Crisis – a modern myth?

They say that life begins at 40. If that is true, then I have four and half years coddled up in the womb of young adulthood before I am birthed into the cold harshness of ‘middle age’. We tend not to think too much of being ‘middle aged’, and we all know someone who has gone through (or is going through) the dreaded ‘midlife crisis’. About a quarter of adults aged over 40 say that they have had such an episode and the story usually goes something like: a 40- or 50-something man splashes his lifesavings on a flashy sportscar or noisy motorbike, starts a rock band, and/or quits his job to swan off with a younger woman. What on Earth could possibly possess a responsible grownup show such sudden reckless abandon? Read more

It’s good to go to work on an egg, as long as it’s not Easter

laughing eggsAs a child, I thought “go to work on an egg” was an advert for oval shaped cars. Starting soon after the end of World War II, “Go to Work on an Egg” was a long-running campaign that became one of the most successful food promotions of all time. Humorous television (see below) and newspaper ads encouraged the British public to eat an egg at breakfast and, by the 1960s, we were each dipping, scrambling and frying our way through five a week. Back then, every doctor in the land said eggs were good for health but come the 1970s our love affair with them started to crack. Medics warned that eggs could raise cholesterol levels and when Conservative MP Edwina Currie suggested that all British eggs might be infected with Salmonella in 1988, egg sales went splat – dropping by 60% overnight. Read more

It’s official: you’re only as old as you feel (and look)

Forever Young by Roberto Ventre on Flickr“You are only as old as you feel,” or so the saying goes. This adage is great for cheering yourself up when the grey hairs start to take root, but science has recently revealed that the time-honoured expression is alive and kicking – the younger you feel, the younger you actually are.

Ground-breaking new research has shown what happens when you follow the lives of 1,000 twenty-somethings over a period of ten years. A team of American and New Zealand scientists monitored each volunteer’s ‘biological of age’ over this period, measuring their ‘true age’ through tests for cholesterol, heart and lung health, immune system function and DNA damage (among other things). Incredibly, they found that each person’s body aged at a different rate. Read more

Get off your bum! Your office chair could be killing you (very slowly)

An office chair. Yesterday.I have some bad news to tell you – are you sitting down? Well, I’m sorry to break it to you, but your office chair could be killing you. I know it looks harmless, with its ergonomic arm rests and comfy sponge seat, but each hour you spend sitting in it could be causing your arteries to harden. That chair could also be making you fatter and even increasing your chances of diabetes. Read more

Dr Stu’s science of bisuit dunking

044 of 366 by Pam loves pie, on FlickrGo on, admit it: you love doing it. Every morning at 11 O’clock, tens of thousands of people prise open the biscuit tin to get ready to do some dunking. It’s a worldwide tea break curiosity that has existed to since the dawn of the sweet baked treat. In America, they do it with doughnuts, while South Africans like to use rusks.

In a tonight’s BBC4 documentary, Nigel Slater’s Great British Biscuit, I explain some of the science of biscuit dunking. Here, more of the mysteries of the dunk are unwrapped… Read more

I can’t tweet without you: How twitter feeds our inner longing for friendship

CreativeTools.se - Twitter bird standing on branch - Close-up by Creative Tools, on FlickrI think I’ve started to feel what it’s like to get old. Strange ‘#’ symbols started to flash up on the TV screen a few months back. Some odd new lottery I wondered? Oblivious to the newest and most important media advancement in the last decade, my friends laughed at my ignorance. Graciously educating me in twitter-speak, they taught me what ‘followers’, @ symbols, retweets and trends were. Since 1988 when an 8-bit Commodore 64 arrived in Christmas gift wrap, I have prided myself in being up to date with tech-culture. It seemed much easier when Mario was a child.

Although I am now twitter fluent, and a regular user, try as I may, I don’t get very excited about it. Like Facebook, it feels a chore – akin to laborious Christmas-card-writing – a necessity to stay digitally ‘connected’. Surely I am in the minority: of twitter’s 140 million (and growing) users, most surely use social media for the joy of it – delighting in sharing life’s experiences day, night and through those crafty under-the-table tweets. Read more

What is really in your takeaway pizza?

Via Via IV by The Pizza Review, on FlickrIt’s a Saturday night. Perhaps you shouldn’t have had that last Babycham, but it’s been a hard week and you deserve it. Now, like a Siren luring you to the rocks, the takeout calls. Will it be the kebab van, the burger joint or pizza parlour?

Unlike tightly regulated franchises, most high street vendors don’t need to consider the healthiness of their portions. What we shovel in our gob on a night out is largely an unknown. A team of calorie committed researchers braved the streets to discover what REALLY is in our favourite celebratory cuisine. In this ‘what is really in your food’ series of blog posts, the first delicacy to be brought into the cold light of day is the pizza… (next time, burgers) Read more

Drinking Alcohol makes you pee more – but how much?

Original 16Too much tipple and you’ll know about it the next day.

The dreaded hangover – headaches, fatigue and nausea are normal Sunday morning sensations for many a Saturday night reveller. Dehydration is frequently said to be the reason for hangover symptoms – and some swear that a pint of tap water before bed thwarts any alcohol-induced ill-effects. But given the amount of fluid drunk during a night on the town, it sounds like quite an odd idea.

So just how dehydrating is alcohol – and can lack of water really explain a hangover? The data is difficult to find: no-one seems very interested in researching hangovers these days. It’s therefore time to blow the digital dust of a seventy year-old research paper to find an answer… Read more